The preparation contains OCHGTM chitosan oligomers in liquid form, which are characterized by their unique ability to directly form polymer membranes from suspension, good miscibility with other biopolymers, and a high secondary swelling index value. Under the influence of digestive enzymes, part of the chitosan oligomers is absorbed into the blood, while the part not digested by enzymes binds water and acts as an absorbent in the digestive tract. Vitamin C supports the immune system and aids in detoxifying the body and neutralizing free radicals.
OCHGTM – patented process for producing bioactive chitosan oligomers.Composition
Recommended daily dose: | 3 teaspoons (15 ml) |
Chitosan lactate (chitosan oligomers) | 525 mg |
Vitamin C | 12 mg/15% RWS* |
* Dietary Reference Value
Impact of Chitosan Oligomers on Human Health
Recent reports from a team of scientists at Jagiellonian University in Krakow, who announced that they had created a substance strongly inhibiting the infection by the SARS-CoV-2 coronavirus, have instilled hope for the development of an effective drug to combat the COVID-19 pandemic.
The researchers demonstrated that the discovered substance consists of polymeric inhibitors. These were created based on chitosan—a compound obtained from marine crustacean shells. The polymer acts by binding to the S protein (SARS-CoV-2), which forms the “spike” of the virus, thereby blocking its interaction with the cellular receptor—angiotensin-converting enzyme II, consequently preventing the virus from penetrating the host cell.
Chitosan has numerous beneficial effects on the body. Specialists refer to it as the sixth essential life component—after proteins, fats, carbohydrates, minerals, and vitamins. It effectively cleanses and deacidifies the body, stimulates human defense mechanisms, inhibits the proliferation of cancer cells, lowers cholesterol levels, and aids in weight reduction. By supplementing with chitosan, many diseases that modern medicine struggles with can be treated.
Chitosan, from which polymeric compounds are derived, is chemically an organic compound from the polysaccharides group; a derivative of chitin, produced through its partial deacetylation. The deacetylation process of chitin involves the removal of acetyl groups, which harden chitin and make it insoluble in a polar aquatic environment. The highest biological activity of chitosan is achieved after its processing in the patented OCHG™ process. As a result, chitosan lactate is obtained, i.e., chitosan in the form of oligomers, with short oligo-sugar chains and strictly controlled molecular weight. Structurally, chitosan is similar to cellulose—an animal-derived fiber, akin to human fibrin. It is completely natural and well tolerated by our bodies, not interacting with normal cells.
Chitosan has numerous beneficial effects on the body. Specialists refer to it as the sixth essential life component—after proteins, fats, carbohydrates, minerals, and vitamins. It effectively cleanses and deacidifies the body, stimulates human defense mechanisms, inhibits the proliferation of cancer cells, lowers cholesterol levels, and aids in weight reduction. By supplementing with chitosan, many diseases that modern medicine struggles with can be treated.
Chitosan, from which polymeric compounds are derived, is chemically an organic compound from the polysaccharides group; a derivative of chitin, produced through its partial deacetylation. The deacetylation process of chitin involves the removal of acetyl groups, which harden chitin and make it insoluble in a polar aquatic environment. The highest biological activity of chitosan is achieved after its processing in the patented OCHG™ process. As a result, chitosan lactate is obtained, i.e., chitosan in the form of oligomers, with short oligo-sugar chains and strictly controlled molecular weight. Structurally, chitosan is similar to cellulose—an animal-derived fiber, akin to human fibrin. It is completely natural and well tolerated by our bodies, not interacting with normal cells.
How Chitosan Oligomers Work
- They enhance the body's immunity by increasing the activity of T lymphocytes,
- Inhibit infections by pathogenic microorganisms,
- Eliminate body acidification, raise pH by acting as a base,
- Act anticancerously, inhibiting the proliferation of cancer cells and the formation of metastases,
- Cleanse the body of heavy metals and other harmful substances (mercury, cadmium, pesticides, artificial dyes),
- Act as hypotensives - lower blood pressure, reduce the contractility of capillaries,
- Improve liver and pancreas function,
- Help control blood sugar levels,
- Lower cholesterol levels, reduce the absorption of fats and cholesterol in the intestines, cleanse blood vessels of cholesterol plaques,
- Protect the mucous membranes of the gastrointestinal tract, effectively accelerate the healing of erosions and ulcers,
- Combat leaky gut syndrome - one of the main causes of allergies and autoimmune diseases,
- Eliminate heartburn, hyperacidity, and bloating,
- Improve the state of intestinal microbiota - cleanse the intestinal villi, improve intestinal peristalsis,
- Increase skin elasticity and joint mobility, strengthen connective and cartilage tissue.
When to Use Chitosan Oligomers
- In the prevention of cardiovascular diseases; atherosclerosis, heart attacks, strokes, and hypertension,
- With reduced immunity and immunological disorders,
- With improper liver and pancreas function and diabetes,
- Candidiasis of the gastrointestinal tract,
- Food poisoning,
- Hyperacidity and heartburn,
- In inflammation, erosions, and ulcers of the gastrointestinal tract,
- In cancer prevention, chemotherapy, radiotherapy, and detoxification.
Chitosan Oligomers Strengthen the Body's Immunity
Experimental studies on microorganisms and viruses involving chitosan have shown inhibition of their development in the host cell. The mechanism of chitosan’s action is based on its positively charged amino groups interacting with negatively charged functional groups found in the cell walls of bacteria or viruses. These electrostatic interactions contribute to changes in the permeability (elasticity) of the cell membrane, leading to its disintegration and the leakage of intracellular substances.
Other authors suggest that chitosan forms a polymeric envelope around the cell membrane of microorganisms, preventing the transport of nutrients into the cell and regulating metabolic processes occurring within it, consequently leading the cell towards apoptosis.
It has been demonstrated that chitosan oligomer molecules have the ability to penetrate the cell membrane of microorganisms and viruses, resulting in binding to their genetic material, DNA or RNA, which leads to the inhibition of replication (doubling of genetic material), transcription (RNA synthesis), and translation (protein synthesis) processes.
Other authors suggest that chitosan forms a polymeric envelope around the cell membrane of microorganisms, preventing the transport of nutrients into the cell and regulating metabolic processes occurring within it, consequently leading the cell towards apoptosis.
It has been demonstrated that chitosan oligomer molecules have the ability to penetrate the cell membrane of microorganisms and viruses, resulting in binding to their genetic material, DNA or RNA, which leads to the inhibition of replication (doubling of genetic material), transcription (RNA synthesis), and translation (protein synthesis) processes.
Chitosan Oligomers Are Indispensable in Cancer Prevention
Chitosan oligomers bind to cancer cells, which have a negatively charged membrane, contributing to the alteration of the membrane’s elasticity to the values of normal cells, changing its permeability, and elevating the pH of the fluid inside and outside the cell to values between 7.35 and 7.4. This promotes the deacidification of the body. Acidification of the body disrupts all biochemical processes, thickens the blood, impairs circulation, heavily burdens the kidneys, causes joint and muscle pain, and encourages the growth of cancer cells. In an alkaline environment, cancer cells do not proliferate. Therefore, when used in higher doses, chitosan causes the death of cancer cells and inhibits their multiplication, which reduces tumor size.
Chitosan Oligomers Cleanse the Body of Toxins and Lower Blood Cholesterol Levels
Chitosan oligomers cleanse the gastrointestinal tract, liver, and the entire body of heavy metals and toxins by binding them and expelling them from the body. Research results indicate that they very effectively improve the condition and function of the liver and pancreas. Chitosan also binds chloride ions from table salt and excretes them, which prevents the formation of angiotensin – a substance that causes a sudden contraction of the vessels. As a result, it acts as a hypotensive agent, lowering blood pressure. The preparation binds and removes cholesterol from the gastrointestinal tract because it has positively charged amino groups at the same pH as the gastrointestinal tract. The amino groups bind to negatively charged particles, such as lipids and bile acids, preventing their absorption and storage by the body. The action of chitosan contributing to the lowering of LDL cholesterol levels can be explained by pointing to the hydrophobic interactions of chitosan salts with fatty acids and lipoprotein lipids. Such bound lipids are excreted from the gastrointestinal tract along with other metabolic products, rather than being reabsorbed as would occur in the process of reverse resorption.
Chitosan Oligomers Improve the Functioning of the Digestive System
Upon dissolution, they create a coating that acts protectively, eliminates hyperacidity, stimulates healing processes, and treats erosions, ulcers, and defects in the mucosa. These mucosal defects are the cause of leaky gut syndrome (“Leaky Gut Syndrome”). Leaky gut syndrome is one of the main causes of allergies and autoimmune diseases, as undigested food components (e.g., casein, gluten) and toxins permeate through holes in the intestinal mucous membrane, enter the bloodstream, and consequently trigger an immune response from the immune system.
Chitosan Oligomers Eliminate Candida
Leaky gut syndrome is often caused by Candida-type yeasts. Candida albicans is a parasitic fungus that lives in the human gastrointestinal tract. If dysbiosis occurs, that is, a disturbance in the proper composition of the gut microbiota, the yeasts begin to multiply and dominate. As a result, they secrete a range of toxins and metabolites that enter the bloodstream and poison the entire body. This adversely affects a number of processes occurring in the body, disrupting its functioning and leading to diseases, including cancer. Chitosan oligomers effectively inhibit the growth of Candida.
This text incorporates the latest literature on SARS-CoV-2 as well as many years of experience in research on chitosan conducted in cooperation with the Department of Medical Biochemistry at the Jagiellonian University Medical College and the Institute of Biopolymers and Chemical Fibers in Łódź.
Dr. Jan Ignacak, Department of Medical Biochemistry, Jagiellonian University Medical College
Source:
Yoshinori Tanaka, Shin-ichiro Tanioka, Miyoko Tanaka Effects of chitin and chitosan particles on BALB/c mice by oral and parenteral administration. Biomaterials 18 (1997) 591-595.
Majeti N.V. Ravi Kumar A reviev of chitin and chitosan applications. Reactive & Functional Polymers 46 (2000) 1-27.
Alemdaroglu C., Zelihagul D., Celebi N., Zor F., Ozturk S., Erdogan D. 2006. An investigation on burn wound healing in rats with chitosan gel formulation containg epidermal growth factor. Burns 32, s. 219-327.
Ignacak J., Wiśniewska-Wrona M.,Pałka I.,Zagajewski J., Niekraszewicz A. 2011. Role of chitosan oligomers in regulation of Ehrlich ascites tumor cells proliferation in vitro. Progress on chemistry and application of chitin and its derivatives, Monograph, vol. XVI, Polish Chitin Society, s. 89.
Ravi Kumar N. V. 2000. A review of chitin and chitosan applications. Reactive & Functional Polymers, 46, s.1-27.
Muzzarelli R.A.A., Muzzarelli C. 2005. Chitosan Chemistry: Relevance to the Biomedical Science. Springer Heidelberg, Berlin.
Ming-Tsung Y., Joan-Hwa Y., Yeng-Leun M. 2008. Antioxidante properties of chitosan from crab shells. Carbohydrate Polymers, 74,4, s.840-844.
Obara K., Ishihara M., Ishizuka T., Fujita M., Ozeki Y., Maehara T., Saito Y.,Yura H., Matsui T., Hattori H., Ki¬kuchi M., Kurita A. 2003. Photocrosslinkable chitosan hydrogel containing fibroblast growth factor-2 stimulates wound healing in healing-impaired db/db mice. Biomaterials, 24, 3437–3444.
Schmitt F., Lagopoulos L., Käuper P., Rossi N., Busso N., Barge J., Wagnières G., Laue C., Wandrey C., Juillerat-Jeanneret L. 2010. Chitosan-based nanogels for selective delivery of photosensitizers to macrophages and improved retention in and therapy of articular joints. Journal Control Research. 1;144(2):242-50.
Sahm Inan D., Unver Saraydm D. 2013. Investigation of the wound healing effects of chitosan on FGFR3 and VEGF immunlocalization in experimentally diabetic rats. International Journal of Biomedical Materials Research, 1 (1) 1-8.
Chitranshi N., et al. 2020. Evolving geographic diversity in SARS-CoV2 and in silico analysis of replicating enzyme 3CLpro targeting repurposed drug candidates. J Transl. Med. 18; 278-293.
Majeti N.V. Ravi Kumar A reviev of chitin and chitosan applications. Reactive & Functional Polymers 46 (2000) 1-27.
Alemdaroglu C., Zelihagul D., Celebi N., Zor F., Ozturk S., Erdogan D. 2006. An investigation on burn wound healing in rats with chitosan gel formulation containg epidermal growth factor. Burns 32, s. 219-327.
Ignacak J., Wiśniewska-Wrona M.,Pałka I.,Zagajewski J., Niekraszewicz A. 2011. Role of chitosan oligomers in regulation of Ehrlich ascites tumor cells proliferation in vitro. Progress on chemistry and application of chitin and its derivatives, Monograph, vol. XVI, Polish Chitin Society, s. 89.
Ravi Kumar N. V. 2000. A review of chitin and chitosan applications. Reactive & Functional Polymers, 46, s.1-27.
Muzzarelli R.A.A., Muzzarelli C. 2005. Chitosan Chemistry: Relevance to the Biomedical Science. Springer Heidelberg, Berlin.
Ming-Tsung Y., Joan-Hwa Y., Yeng-Leun M. 2008. Antioxidante properties of chitosan from crab shells. Carbohydrate Polymers, 74,4, s.840-844.
Obara K., Ishihara M., Ishizuka T., Fujita M., Ozeki Y., Maehara T., Saito Y.,Yura H., Matsui T., Hattori H., Ki¬kuchi M., Kurita A. 2003. Photocrosslinkable chitosan hydrogel containing fibroblast growth factor-2 stimulates wound healing in healing-impaired db/db mice. Biomaterials, 24, 3437–3444.
Schmitt F., Lagopoulos L., Käuper P., Rossi N., Busso N., Barge J., Wagnières G., Laue C., Wandrey C., Juillerat-Jeanneret L. 2010. Chitosan-based nanogels for selective delivery of photosensitizers to macrophages and improved retention in and therapy of articular joints. Journal Control Research. 1;144(2):242-50.
Sahm Inan D., Unver Saraydm D. 2013. Investigation of the wound healing effects of chitosan on FGFR3 and VEGF immunlocalization in experimentally diabetic rats. International Journal of Biomedical Materials Research, 1 (1) 1-8.
Chitranshi N., et al. 2020. Evolving geographic diversity in SARS-CoV2 and in silico analysis of replicating enzyme 3CLpro targeting repurposed drug candidates. J Transl. Med. 18; 278-293.